Avoidant symptoms in PTSD predict fear circuit activation during multimodal fear extinction
Identifieur interne : 000118 ( Main/Exploration ); précédent : 000117; suivant : 000119Avoidant symptoms in PTSD predict fear circuit activation during multimodal fear extinction
Auteurs : Rebecca K. Sripada [États-Unis] ; Sarah N. Garfinkel [Royaume-Uni] ; Israel Liberzon [États-Unis]Source :
- Frontiers in Human Neuroscience [ 1662-5161 ] ; 2013.
Abstract
Convergent evidence suggests that individuals with posttraumatic stress disorder (PTSD) exhibit exaggerated avoidance behaviors as well as abnormalities in Pavlonian fear conditioning. However, the link between the two features of this disorder is not well understood. In order to probe the brain basis of aberrant extinction learning in PTSD, we administered a multimodal classical fear conditioning/extinction paradigm that incorporated affectively relevant information from two sensory channels (visual and tactile) while participants underwent fMRI scanning. The sample consisted of fifteen OEF/OIF veterans with PTSD. In response to conditioned cues and contextual information, greater avoidance symptomatology was associated with greater activation in amygdala, hippocampus, vmPFC, dmPFC, and insula, during both fear acquisition and fear extinction. Heightened responses to previously conditioned stimuli in individuals with more severe PTSD could indicate a deficiency in safety learning, consistent with PTSD symptomatology. The close link between avoidance symptoms and fear circuit activation suggests that this symptom cluster may be a key component of fear extinction deficits in PTSD and/or may be particularly amenable to change through extinction-based therapies.
Url:
DOI: 10.3389/fnhum.2013.00672
PubMed: 24146643
PubMed Central: 3797966
Affiliations:
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Sripada</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, University of Michigan</institution><country>Ann Arbor, MI, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Veterans Affairs Center for Clinical Management Research, Department of Veterans Affairs Healthcare System</institution><country>Ann Arbor, MI, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Garfinkel, Sarah N" sort="Garfinkel, Sarah N" uniqKey="Garfinkel S" first="Sarah N." last="Garfinkel">Sarah N. Garfinkel</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Psychiatry, Brighton and Sussex Medical School</institution><country>Brighton, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Liberzon, Israel" sort="Liberzon, Israel" uniqKey="Liberzon I" first="Israel" last="Liberzon">Israel Liberzon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, University of Michigan</institution><country>Ann Arbor, MI, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea></wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Human Neuroscience</title><idno type="eISSN">1662-5161</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Convergent evidence suggests that individuals with posttraumatic stress disorder (PTSD) exhibit exaggerated avoidance behaviors as well as abnormalities in Pavlonian fear conditioning. However, the link between the two features of this disorder is not well understood. In order to probe the brain basis of aberrant extinction learning in PTSD, we administered a multimodal classical fear conditioning/extinction paradigm that incorporated affectively relevant information from two sensory channels (visual and tactile) while participants underwent fMRI scanning. The sample consisted of fifteen OEF/OIF veterans with PTSD. In response to conditioned cues and contextual information, greater avoidance symptomatology was associated with greater activation in amygdala, hippocampus, vmPFC, dmPFC, and insula, during both fear acquisition and fear extinction. Heightened responses to previously conditioned stimuli in individuals with more severe PTSD could indicate a deficiency in safety learning, consistent with PTSD symptomatology. 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Reiser</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Sripada, Rebecca K" sort="Sripada, Rebecca K" uniqKey="Sripada R" first="Rebecca K." last="Sripada">Rebecca K. Sripada</name></noRegion><name sortKey="Liberzon, Israel" sort="Liberzon, Israel" uniqKey="Liberzon I" first="Israel" last="Liberzon">Israel Liberzon</name><name sortKey="Sripada, Rebecca K" sort="Sripada, Rebecca K" uniqKey="Sripada R" first="Rebecca K." last="Sripada">Rebecca K. Sripada</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Garfinkel, Sarah N" sort="Garfinkel, Sarah N" uniqKey="Garfinkel S" first="Sarah N." last="Garfinkel">Sarah N. Garfinkel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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